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Article

Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy.

Journal of viral hepatitis - 1 Jun 2011

Coffin C S, Mulrooney-Cousins P M, Peters M G, van Marle G, Roberts J P, Michalak T I, Terrault N A

Abstract excerpt

The hepatitis B virus (HBV) replicates via an error-prone reverse transcriptase generating potential drug-resistant quasispecies. The degree of HBV variability in liver vs peripheral blood mononuclear cells (PBMC) in patients on long-term suppressive antivirals is unclear. We characterized HBV replication, drug resistance and molecular diversity in patients with plasma HBV DNA undetectable by clinical assays....

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Identifiers

PMID: 20626626
DOI: 10.1111/j.1365-2893.2010.01321.x
PMCID: PMC4142495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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