Functional polymorphisms of the microsomal epoxide hydrolase gene: a reappraisal on a early-onset lung cancer patients series.

doi:10.1016/j.lungcan.2008.05.004

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Functional polymorphisms of the microsomal epoxide hydrolase gene: a reappraisal on a early-onset lung cancer patients series.

Lung cancer (Amsterdam, Netherlands) - 1 Feb 2009

Graziano Claudio, Comin Camilla Eva, Crisci Clemente, Novelli Luca, Politi Leonardo, Messerini Luca, Andreani Matteo, Porfirio Berardino

Abstract excerpt

Microsomal epoxide hydrolase gene (EPHX1) is polymorphic and encodes an enzyme involved in both the activation and detoxification of several tobacco carcinogens. Therefore, a contribution of EPHX1 enzymatic activity on lung cancer risk is possible. A genetic component of early-onset lung cancer has been suggested but variations in enzyme activity and polymorphisms in EPHX1 have seldom been studied in young...

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Functional polymorphisms of the microsomal epoxide hydrolase gene: a reappraisal on a early-onset lung cancer patients series.

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Functional polymorphisms of the microsomal epoxide hydrolase gene: a reappraisal on a early-onset lung cancer patients series.

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