Increased "absence" of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome.

doi:10.1016/j.neulet.2008.05.098

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Increased "absence" of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome.

Neuroscience letters - 8 Aug 2008

Jenkins Edmund C, Ye Lingling, Gu Hong, Ni Samantha A, Duncan Charlotte J, Velinov Milen, Pang Deborah, Krinsky-McHale Sharon J, Zigman Warren B, Schupf Nicole, Silverman Wayne P

Abstract excerpt

We have reported previously that telomeres (ends of chromosomes consisting of highly conserved TTAGGG repeats) were shorter in metaphase and interphase preparations in T lymphocytes from short-term whole blood cultures of women with Down syndrome (DS) and dementia compared to age-matched women with DS but without dementia [E.C. Jenkins, M.T. Velinov, L. Ye, H. Gu, S. Li, E.C. Jenkins Jr., S.S. Brooks, D. Pang,...

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Increased "absence" of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome.

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