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Article

Telomere longitudinal shortening as a biomarker for dementia status of adults with Down syndrome

23 Nov 2015

Abstract excerpt

Previous studies have suggested that Alzheimer's disease (AD) causes an accelerated shortening of telomeres, the ends of chromosomes consisting of highly conserved TTAGGG repeats that, because of unidirectional 5'-3' DNA synthesis, lose end point material with each cell division. Our own previous work suggested that telomere length of T-lymphocytes might be a remarkably accurate biomarker for "mild cognitive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26593971
DOI: 10.1002/ajmg.b.32389

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