Article
Telomere length is not predictive of dementia or MCI conversion in the oldest old.
Neurobiology of aging - 1 Apr 2010
Zekry Dina, Herrmann François R, Irminger-Finger Irmingard, Ortolan Laura, Genet Chantal, Vitale Anna-Maria, Michel Jean-Pierre, Gold Gabriel, Krause Karl-Heinz
Abstract excerpt
The contribution of telomere shortening to the onset of certain age-related diseases, such as dementia, and its role as a predictor of cognitive impairment remain unclear. We tested these hypotheses by analyzing telomere length in 449 inpatients in a large cohort of the oldest old (mean age 85 years) followed up yearly. No significant difference in telomere length was observed between cognitively normal patients...
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