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Article

Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia.

Neurobiology of aging - 1 Jul 2006

Jenkins Edmund C, Velinov Milen T, Ye Lingling, Gu Hong, Li Shuyun, Jenkins Edmund C, Brooks Susan Sklower, Pang Deborah, Devenny Darlynne A, Zigman Warren B, Schupf Nicole, Silverman Wayne P

Abstract excerpt

Telomere shortening has been recently correlated with Alzheimer's disease status. Therefore, we hypothesized that a possible association might exist for adults with Down syndrome (DS). Using blind, quantitative telomere protein nucleic acid FISH analyses of metaphase and interphase preparations from 18 age-matched trisomy 21 female study participants with and without dementia, we have observed increased telomere...

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Identifiers

PMID: 16046031
DOI: 10.1016/j.neurobiolaging.2005.05.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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