VEGF signaling governs the initiation of biliary-mediated liver regeneration through the PI3K-mTORC1 axis

Abstract excerpt

Biliary epithelial cells (BECs) are a potential source to repair the damaged liver when hepatocyte proliferation is compromised. Promotion of BEC-to-hepatocyte transdifferentiation could be beneficial to the clinical therapeutics of patients with end-stage liver diseases. However, mechanisms underlying the initiation of BEC transdifferentiation remain largely unknown. Here, we show that upon extreme hepatocyte...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Liver physiology and pathology
• Share to Organ Transplantation Techniques and Outcomes
• Share to Pancreatic function and diabetes