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Article

Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice.

Gastroenterology - 1 Apr 2012

Dill Michael T, Rothweiler Sonja, Djonov Valentin, Hlushchuk Ruslan, Tornillo Luigi, Terracciano Luigi, Meili-Butz Silvia, Radtke Freddy, Heim Markus H, Semela David

Abstract excerpt

BACKGROUND & AIMS: Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH). The pathogenesis of NRH is unclear, but has been associated with vascular injury in the liver sinusoids in clinical studies. We investigated the role of Notch1 signaling in liver sinusoidal endothelial cells (LSECs). METHODS: We studied...

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PMID: 22245843
DOI: 10.1053/j.gastro.2011.12.052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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