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Article

Angiogenesis-independent endothelial protection of liver: role of VEGFR-1.

Science (New York, N.Y.) - 7 Feb 2003

LeCouter Jennifer, Moritz Dirk R, Li Bing, Phillips Gail Lewis, Liang Xiao Huan, Gerber Hans-Peter, Hillan Kenneth J, Ferrara Napoleone

Abstract excerpt

The vascular endothelium was once thought to function primarily in nutrient and oxygen delivery, but recent evidence suggests that it may play a broader role in tissue homeostasis. To explore the role of sinusoidal endothelial cells (LSECs) in the adult liver, we studied the effects of vascular endothelial growth factor (VEGF) receptor activation on mouse hepatocyte growth. Delivery of VEGF-A increased liver mass...

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Source

Identifiers

PMID: 12574630
DOI: 10.1126/science.1079562

Genes

HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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