Article
The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype.
The Journal of pathology - 1 Sept 2008
Vockerodt M, Morgan S L, Kuo M, Wei W, Chukwuma M B, Arrand J R, Kube D, Gordon J, Young L S, Woodman C B, Murray P G
Abstract excerpt
Although the latent membrane protein-1 (LMP1) of the Epstein-Barr virus (EBV) is believed to be important for the transformation of germinal centre (GC) B cells, the precise contribution of this viral oncogene to lymphoma development is poorly understood. In this study, we used a non-viral vector-based method to express LMP1 in primary human GC B cells. Gene expression profiling revealed that LMP1 induced in GC B...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.