Suppression of the LMP2A target gene, EGR ‐1, protects Hodgkin's lymphoma cells from entry to the EBV lytic cycle

doi:10.1002/path.4198

Article

Suppression of the LMP2A target gene, EGR ‐1, protects Hodgkin's lymphoma cells from entry to the EBV lytic cycle

16 Apr 2013

Abstract excerpt

Hodgkin's lymphoma is unusual among B cell lymphomas, in so far as the malignant Hodgkin/Reed-Sternberg (HRS) cells lack a functional B cell receptor (BCR), as well as many of the required downstream signalling components. In Epstein-Barr virus (EBV)-positive cases of Hodgkin's lymphoma, HRS cells express the viral latent membrane proteins (LMP)-1 and -2A. LMP2A is thought to contribute to the pathogenesis of...

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