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Article

Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway.

The Journal of biological chemistry - 29 Aug 2008

Xia Zanxian, Webster Ailsa, Du Fangyong, Piatkov Konstantin, Ghislain Michel, Varshavsky Alexander

Abstract excerpt

Substrates of a ubiquitin-dependent proteolytic system called the N-end rule pathway include proteins with destabilizing N-terminal residues. N-recognins, the pathway's ubiquitin ligases, contain three substrate-binding sites. The type-1 site is specific for basic N-terminal residues (Arg, Lys, and His). The type-2 site is specific for bulky hydrophobic N-terminal residues (Trp, Phe, Tyr, Leu, and Ile). We show...

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Identifiers

PMID: 18566452
DOI: 10.1074/jbc.M802583200
PMCID: PMC2527112

Genes

UBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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