Article
Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates.
Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2022
Kim Bong Heon, Kim Min Kyung, Oh Sun Joo, Nguyen Kha The, Kim Jun Hoe, Varshavsky Alexander, Hwang Cheol-Sang, Song Hyun Kyu
Abstract excerpt
N-degron pathways are proteolytic systems that target proteins bearing N-terminal (Nt) degradation signals (degrons) called N-degrons. Nt-Arg of a protein is among Nt-residues that can be recognized as destabilizing ones by the Arg/N-degron pathway. A proteolytic cleavage of a protein can generate Arg at the N terminus of a resulting C-terminal (Ct) fragment either directly or after Nt-arginylation of that...
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