Article
Bivalent inhibitor of the N-end rule pathway.
The Journal of biological chemistry - 18 Jun 1999
Kwon Y T, Lévy F, Varshavsky A
Abstract excerpt
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Ubr1p, the recognition (E3) component of the Saccharomyces cerevisiae N-end rule pathway, contains at least two substrate-binding sites. The type 1 site is specific for N-terminal basic residues Arg, Lys, and His. The type 2 site is specific for N-terminal bulky hydrophobic residues Phe, Leu, Trp, Tyr, and Ile....
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