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Article

N-recognin/Ubc2 interactions in the N-end rule pathway.

The Journal of biological chemistry - 5 Jun 1993

Madura K, Dohmen R J, Varshavsky A

Abstract excerpt

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. In the yeast Saccharomyces cerevisiae, substrates of the N-end rule pathway are targeted for degradation by a complex that includes the 225-kDa N-recognin, encoded by UBR1, and the 20-kDa ubiquitin-conjugating enzyme encoded by UBC2. We report that both physical stability and functional activity of the...

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Source

Identifiers

PMID: 8505328

Genes

UBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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One functional subunit is sufficient for catalytic activity and substrate specificity of Escherichia coli endoribonuclease III artificial heterodimers.Semantic proximity Read ↗

Identification of a substrate recognition site on Ubc9.Semantic proximity Read ↗

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