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Article

The type-2 N-end rule peptide recognition activity of Ubr11 ubiquitin ligase is required for the expression of peptide transporters.

FEBS letters - 16 Jan 2013

Kitamura Kenji, Fujiwara Hidenobu

Abstract excerpt

The Ubr1-like canonical N-recognins, widely conserved ubiquitin ligases in eukaryotes, play a role in the N-end rule pathway-mediated degradation of substrates harboring basic (type-1) or bulky hydrophobic (type-2) amino acids at the N-terminus. In this study, the roles of conserved domains were studied in the Schizosaccharomyces pombe Ubr11 protein. Mutations in the UBR box and the autoinhibitory domain blocked...

Topics

Conserved Sequence
Gene Expression
Genes, Fungal
Membrane Transport Proteins
Mutation
Protein Structure, Tertiary
Recombinant Proteins
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Ubiquitin-Protein Ligases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23219921
DOI: 10.1016/j.febslet.2012.11.028

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