Article
CTL-promoting effects of CD40 stimulation outweigh B cell-stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2008
Puliaev Roman, Puliaeva Irina, Welniak Lisbeth A, Ryan Abigail E, Haas Mark, Murphy William J, Via Charles S
Abstract excerpt
CD40/CD40L signaling promotes both B cell and CTL responses in vivo, the latter being beneficial in tumor models. Because CTL may also limit autoreactive B cell expansion in lupus, we asked whether an agonist CD40 mAb would exacerbate lupus due to B cell stimulation or would improve lupus due to CTL promotion. These studies used an induced model of lupus, the parent-into-F1 model in which transfer of DBA/2...
Topics
- Animals
- Antibodies, Monoclonal
- B-Lymphocytes
- CD4-Positive T-Lymphocytes
- CD40 Antigens
- Cells, Cultured
- Cytotoxicity, Immunologic
- Dendritic Cells
- Disease Models, Animal
- Graft vs Host Disease
- Lupus Erythematosus, Systemic
- Lymphocyte Activation