Article
Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2006
Recchia Alessandra, Bonini Chiara, Magnani Zulma, Urbinati Fabrizia, Sartori Daniela, Muraro Sara, Tagliafico Enrico, Bondanza Attilio, Stanghellini Maria Teresa Lupo, Bernardi Massimo, Pescarollo Alessandra, Ciceri Fabio, Bordignon Claudio, Mavilio Fulvio
Abstract excerpt
The use of retroviral vectors in gene therapy has raised safety concerns for the genotoxic risk associated with their uncontrolled insertion into the human genome. We have analyzed the consequences of retroviral transduction in T cells from leukemic patients treated with allogeneic stem cell transplantation and donor lymphocytes genetically modified with a suicide gene (HSV-TK). Retroviral vectors integrate...
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