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Article

Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2008

Burt Trevor D, Agan Brian K, Marconi Vincent C, He Weijing, Kulkarni Hemant, Mold Jeffrey E, Cavrois Marielle, Huang Yadong, Mahley Robert W, Dolan Matthew J, McCune Joseph M, Ahuja Sunil K

Abstract excerpt

Originally recognized for their role in lipoprotein metabolism and cardiovascular disease, apolipoprotein (apo) E isoforms (apoE2, apoE3, and apoE4) have also been implicated to play a key role in several biological processes not directly related to their lipid transport function. For example, apoE4 contributes significantly to neurodegeneration in Alzheimer's disease. However, the role of apoE in infectious...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18562290
DOI: 10.1073/pnas.0803526105
PMCID: PMC2438419

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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