HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy.

doi:10.1038/2677

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Article

HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy.

Nature medicine - 1 Oct 1998

Corder E H, Robertson K, Lannfelt L, Bogdanovic N, Eggertsen G, Wilkins J, Hall C

Abstract excerpt

HIV produces a chronic viral infection of the central nervous system that elicits chronic glial activation and overexpression of glial cytokines that are also implicated in Alzheimer disease (AD) pathogenesis. A genetic risk factor for AD is the E4 isoform for apolipoprotein E (APOE). Here we com...

Topics

AIDS Dementia Complex
Adult
Alleles
Apolipoprotein E4
Apolipoproteins E
Cohort Studies
Female
HIV Infections
Humans
Male
Middle Aged
Peripheral Nervous System Diseases
Prospective Studies
Protein Isoforms

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