Article
HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy.
Nature medicine - 1 Oct 1998
Corder E H, Robertson K, Lannfelt L, Bogdanovic N, Eggertsen G, Wilkins J, Hall C
Abstract excerpt
HIV produces a chronic viral infection of the central nervous system that elicits chronic glial activation and overexpression of glial cytokines that are also implicated in Alzheimer disease (AD) pathogenesis. A genetic risk factor for AD is the E4 isoform for apolipoprotein E (APOE). Here we compare the frequency of neurologic symptoms for subjects with and without the E4 isoform (E4(+)and E4(-), respectively)...
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