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Article

Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers.

AIDS (London, England) - 28 Nov 2012

Soontornniyomkij Virawudh, Moore David J, Gouaux Ben, Soontornniyomkij Benchawanna, Tatro Erick T, Umlauf Anya, Masliah Eliezer, Levine Andrew J, Singer Elyse J, Vinters Harry V, Gelman Benjamin B, Morgello Susan, Cherner Mariana, Grant Igor, Achim Cristian L

Abstract excerpt

OBJECTIVE: The apolipoprotein E (APOE) ε4 allele enhances cerebral accumulation of β-amyloid (Aβ) and is a major risk factor for sporadic Alzheimer's disease. We hypothesized that HIV-associated neurocognitive disorders (HAND) would be associated with the APOE ε4 genotype and cerebral Aβ deposition. DESIGN: Clinicopathological study of HIV-infected adults from four prospective cohorts in the US National NeuroAIDS...

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Source

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Identifiers

PMID: 23018443
DOI: 10.1097/QAD.0b013e32835a117c
PMCID: PMC3576852

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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