Article
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
Cell - 19 Oct 2001
Vaziri H, Dessain S K, Ng Eaton E, Imai S I, Frye R A, Pandita T K, Guarente L, Weinberg R A
Abstract excerpt
DNA damage-induced acetylation of p53 protein leads to its activation and either growth arrest or apoptosis. We show here that the protein product of the gene hSIR2(SIRT1), the human homolog of the S. cerevisiae Sir2 protein known to be involved in cell aging and in the response to DNA damage, binds and deacetylates the p53 protein with a specificity for its C-terminal Lys382 residue, modification of which has...
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