Article
The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function.
Nucleic acids research - 11 Aug 1994
Chamberlain N L, Driver E D, Miesfeld R L
Abstract excerpt
Some transcription factors contain stretches of polyglutamine encoded by repeats of the trinucleotide CAG. Expansion of the CAG repeat in the androgen receptor (AR) has been correlated with the incidence and severity of X-linked spinal and bulbar muscular atrophy (Kennedy's disease). In order to...
Topics
- Animals
- Base Sequence
- Blotting, Western
- Cell Line
- Genes, Reporter
- Haplorhini
- Humans
- Huntington Disease
- Kidney
- Molecular Sequence Data
- Motor Neurons
- Muscular Atrophy, Spinal
- Mutation
- Receptors, Androgen
- Repetitive Sequences, Nucleic Acid
- Transcription, Genetic
- Transcriptional Activation
- Transfection