Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function.

Nucleic acids research - 11 Aug 1994

Chamberlain N L, Driver E D, Miesfeld R L

Abstract excerpt

Some transcription factors contain stretches of polyglutamine encoded by repeats of the trinucleotide CAG. Expansion of the CAG repeat in the androgen receptor (AR) has been correlated with the incidence and severity of X-linked spinal and bulbar muscular atrophy (Kennedy's disease). In order to understand the relationship of this mutation to AR function, we constructed ARs that varied in the position and size of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Blotting, Western
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Repetitive Sequences, Nucleic Acid

Share to Transcription, Genetic

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 8065934
DOI: 10.1093/nar/22.15.3181
PMCID: PMC310294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function.PMID 8065934Read ↗

CAG-repeat expansion in androgen receptor in Kennedy's disease is not a loss of function mutation.Semantic proximity Read ↗

Spinal and bulbar muscular atrophy: androgen receptor dysfunction caused by a trinucleotide repeat expansion.Semantic proximity Read ↗

Truncated forms of the androgen receptor are associated with polyglutamine expansion in X-linked spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Androgen receptor transactivation domain and control of spermatogenesis.Semantic proximity Read ↗

Role of the androgen receptor CAG repeat polymorphism in prostate cancer, and spinal and bulbar muscular atrophy.Semantic proximity Read ↗

The androgen receptor's CAG/glutamine tract in mouse models of neurological disease and cancer.Semantic proximity Read ↗

The CAG repeat polymorphism within the androgen receptor gene and maleness<sup>1</sup>Semantic proximity Read ↗

Significance of the CAG repeat length in the androgen receptor gene (AR) for the transactivation function of an M780I mutant AR.Semantic proximity Read ↗

Long Polyglutamine Tracts in the Androgen Receptor Are Associated with Reduced<i>Trans</i>-Activation, Impaired Sperm Production, and Male Infertility<sup>1</sup>Semantic proximity Read ↗

Defects of androgen receptor function: from sex reversal to motor neurone disease.Semantic proximity Read ↗

Effect of a short CAG (glutamine) repeat on human androgen receptor function.Semantic proximity Read ↗

The polyglutamine tract of androgen receptor: from functions to dysfunctions in motor neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.