Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spinal and bulbar muscular atrophy: androgen receptor dysfunction caused by a trinucleotide repeat expansion.

Journal of the neurological sciences - 1 Feb 1996

MacLean H E, Warne G L, Zajac J D

Abstract excerpt

Kennedy's disease (spinal and bulbar muscular atrophy) is an X-linked form of motor neuron disease that affects adult men. The syndrome is characterized by progressive atrophy of the limb muscles, pelvic and shoulder girdles and dysphagia and dysarthria, and is caused by the degeneration of spinal and bulbar motor neurons. Kennedy's disease is caused by a trinucleotide repeat expansion of a CAG repeat in exon A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Motor Neuron Disease
Share to Mutation
Share to Nerve Degeneration

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymerase Chain Reaction

Share to Receptors, Androgen

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 8867071
DOI: 10.1016/0022-510x(95)00284-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spinal and bulbar muscular atrophy: androgen receptor dysfunction caused by a trinucleotide repeat expansion.PMID 8867071Read ↗

Defects of androgen receptor function: from sex reversal to motor neurone disease.Semantic proximity Read ↗

Androgen receptor mutation in Kennedy's disease.Semantic proximity Read ↗

Kennedy's disease: a clinicopathologic correlation with mutations in the androgen receptor gene.Semantic proximity Read ↗

Kennedy's disease: pathogenesis and clinical approaches.Semantic proximity Read ↗

CAG-repeat expansion in androgen receptor in Kennedy's disease is not a loss of function mutation.Semantic proximity Read ↗

Phenotypic manifestations associated with CAG-repeat expansion in the androgen receptor gene in male patients and heterozygous females: a clinical and molecular study of 30 families.Semantic proximity Read ↗

Beyond motor neurons: expanding the clinical spectrum in Kennedy's disease.Semantic proximity Read ↗

Trinucleotide repeat disease. The androgen receptor in spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Polymorphic CAG repeat length in the androgen receptor gene and association with neurodegeneration in a heterozygous female carrier of Kennedy's disease.Semantic proximity Read ↗

Spinal and bulbar muscular atrophy: a motoneuron or muscle disease?Semantic proximity Read ↗

The polyglutamine tract of androgen receptor: from functions to dysfunctions in motor neurons.Semantic proximity Read ↗

The androgen receptor's CAG/glutamine tract in mouse models of neurological disease and cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.