Spinal and bulbar muscular atrophy: androgen receptor dysfunction caused by a trinucleotide repeat expansion.

doi:10.1016/0022-510x(95)00284-9

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Article

Spinal and bulbar muscular atrophy: androgen receptor dysfunction caused by a trinucleotide repeat expansion.

Journal of the neurological sciences - 1 Feb 1996

MacLean H E, Warne G L, Zajac J D

Abstract excerpt

Kennedy's disease (spinal and bulbar muscular atrophy) is an X-linked form of motor neuron disease that affects adult men. The syndrome is characterized by progressive atrophy of the limb muscles, pelvic and shoulder girdles and dysphagia and dysarthria, and is caused by the degeneration of spina...

Topics

Animals
Humans
Motor Neuron Disease
Muscular Atrophy
Mutation
Nerve Degeneration
Polymerase Chain Reaction
Receptors, Androgen
Trinucleotide Repeats

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