Article
Abnormalities of germ cell maturation and sertoli cell cytoskeleton in androgen receptor 113 CAG knock-in mice reveal toxic effects of the mutant protein.
The American journal of pathology - 1 Jan 2006
Yu Zhigang, Dadgar Nahid, Albertelli Megan, Scheller Arno, Albin Roger L, Robins Diane M, Lieberman Andrew P
Abstract excerpt
An unresolved question in the study of the polyglutamine neurodegenerative disorders is the extent to which partial loss of normal function of the mutant protein contributes to the disease phenotype. To address this, we studied Kennedy disease, a degenerative disorder of lower motor neurons caused by a CAG/glutamine expansion in the androgen receptor (Ar) gene. Signs of partial androgen insensitivity, including...
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