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Article

Androgen receptor mutation in Kennedy's disease.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jun 1999

Fischbeck K H, Lieberman A, Bailey C K, Abel A, Merry D E

Abstract excerpt

Kennedy's disease is an X-linked form of motor neuron disease caused by an expanded polyglutamine repeat in the androgen receptor. While the expansion mutation causes some loss of transcriptional activity by the androgen receptor, the predominant effect of expansion is probably a toxic gain of function, similar to the mechanism of other polyglutamine expansion diseases. Features of the neurodegenerative phenotype...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10434308
DOI: 10.1098/rstb.1999.0461
PMCID: PMC1692603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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