Article
Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 2006
Albertelli Megan A, Scheller Arno, Brogley Michele, Robins Diane M
Abstract excerpt
Polymorphism in the length of the N-terminal glutamine (Q) tract in the human androgen receptor (AR) has been implicated in affecting aspects of male health ranging from fertility to cancer. Extreme expansion of the tract underlies Kennedy disease, and in vitro the AR Q tract length correlates in...
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