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Article

Prognostic potential of the MDM2 309T>G polymorphism in stage I lung adenocarcinoma.

Cancer medicine - 1 Aug 2016

Enokida Yasuaki, Shimizu Kimihiro, Atsumi Jun, Kakegawa Seiichi, Takase Yoshiaki, Kaira Kyoichi, Yashima Hideaki, Araki Takuya, Nakazawa Seshiru, Ohtaki Yoichi, Nagashima Toshiteru, Alexander Lezhava, Usui Kengo, Ishikawa Toshihisa, Hayashizaki Yoshihide, Takeyoshi Izumi

Abstract excerpt

The MDM2 protein plays an important role in the regulation of cell proliferation and apoptosis via ubiquitination and proteasome-mediated degradation of p53. The genetic polymorphism rs2279744 (c.309T>G) of the MDM2 gene is reportedly associated with susceptibility and/or prognosis in various cancers. In this study, we investigated the risk factors for worse survival in patients with lung adenocarcinoma (AC). We...

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Source

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Identifiers

PMID: 27228500
DOI: 10.1002/cam4.750
PMCID: PMC4884639

Genes

MDM2
EGFR
KRAS

Variants

rs2279744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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