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Article

Inherited Mutations in Women With Ovarian Carcinoma.

JAMA oncology - 1 Apr 2016

Norquist Barbara M, Harrell Maria I, Brady Mark F, Walsh Tom, Lee Ming K, Gulsuner Suleyman, Bernards Sarah S, Casadei Silvia, Yi Qian, Burger Robert A, Chan John K, Davidson Susan A, Mannel Robert S, DiSilvestro Paul A, Lankes Heather A, Ramirez Nilsa C, King Mary Claire, Swisher Elizabeth M, Birrer Michael J

Abstract excerpt

IMPORTANCE: Germline mutations in BRCA1 and BRCA2 are relatively common in women with ovarian, fallopian tube, and peritoneal carcinoma (OC) causing a greatly increased lifetime risk of these cancers, but the frequency and relevance of inherited mutations in other genes is less well characterized. OBJECTIVE: To determine the frequency and importance of germline mutations in cancer-associated genes in OC. DESIGN,...

Topics

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Aged
Aged, 80 and over
Disease-Free Survival
DNA Mutational Analysis
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

Proportional Hazards Models

Source

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Identifiers

PMID: 26720728
DOI: 10.1001/jamaoncol.2015.5495
PMCID: PMC4845939

Genes

BRCA2
BRCA1
BARD1
BRIP1
PALB2
MLH1
MSH2
MSH6
PMS2

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