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BRCA mutations: Implications of genetic testing in ovarian cancer.

Indian journal of cancer - 1 Mar 2022

Talwar Vineet, Rauthan Amit

Abstract excerpt

Ovarian cancer (OC) is one of the most lethal gynecological cancers with a 5-year survival rate that ranges from 30% to 40%. Breast cancer genes (BRCA1 and BRCA2) play a key role in maintaining genomic stability. Mutations in BRCA1/2 genes lead to the accumulation of double-strand breaks, resulting in tumorigenesis. The risk of developing OC in women with BRCA1 and BRCA2 mutations is 39% and 11%, respectively, by...

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BRCA1 Protein
BRCA2 Protein
Carcinoma, Ovarian Epithelial
Genes, BRCA1
Genetic Testing
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

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PMID: 35343191
DOI: 10.4103/ijc.IJC_1394_20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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