Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer.

doi:10.1136/jmedgenet-2015-103672

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Article

Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer.

Journal of medical genetics - 1 Jul 2016

Kast Karin, Rhiem Kerstin, Wappenschmidt Barbara, Hahnen Eric, Hauke Jan, Bluemcke Britta, Zarghooni Verena, Herold Natalie, Ditsch Nina, Kiechle Marion, Braun Michael, Fischer Christine, Dikow Nicola, Schott Sarah, Rahner Nils, Niederacher Dieter, Fehm Tanja, Gehrig Andrea, Mueller-Reible Clemens, Arnold Norbert, Maass Nicolai, Borck Guntram, de Gregorio Nikolaus, Scholz Caroline, Auber Bernd, Varon-Manteeva Raymonda, Speiser Dorothee, Horvath Judit, Lichey Nadine, Wimberger Pauline, Stark Sylvia, Faust Ulrike, Weber Bernhard H F, Emons Gunter, Zachariae Silke, Meindl Alfons, Schmutzler Rita K, Engel Christoph

Abstract excerpt

PURPOSE: To characterise the prevalence of pathogenic germline mutations in BRCA1 and BRCA2 in families with breast cancer (BC) and ovarian cancer (OC) history. PATIENTS AND METHODS: Data from 21 401 families were gathered between 1996 and 2014 in a clinical setting in the German Consortium for Hereditary Breast and Ovarian Cancer, comprising full pedigrees with cancer status of all individual members at the time...

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Identifiers

PMID: 26928436
DOI: 10.1136/jmedgenet-2015-103672

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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