Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of nonnucleoside reverse-transcriptase inhibitor-resistant HIV-1 after discontinuation of virologically suppressive antiretroviral therapy.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Aug 2008

Hare C Bradley, Mellors John, Krambrink Amy, Su Zhaohui, Skiest Daniel, Margolis David M, Patel Sheran S, Barnas Douglas, Frenkel Lisa, Coombs Robert W, Aweeka Francesca, Morse Gene D, Haas David W, Boltz Valerie, Palmer Sarah, Coffin John, Havlir Diane V

Abstract excerpt

Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor-associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reverse-transcriptase inhibitor-containing antiretroviral therapy. Resistance was detected in 45% and 14% of subjects with a baseline human immunodeficiency virus type 1 RNA level of 51-400...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Administration Schedule

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to HIV Infections

Share to Mutation

Share to Reverse Transcriptase Inhibitors

Share to Viral Load

Source

Open in PubMed Open full text

Identifiers

PMID: 18558886
DOI: 10.1086/589867
PMCID: PMC2586907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of nonnucleoside reverse-transcriptase inhibitor-resistant HIV-1 after discontinuation of virologically suppressive antiretroviral therapy.PMID 18558886Read ↗

Reversal periods and patterns from drug-resistant to wild-type HIV type 1 after cessation of anti-HIV therapy.Semantic proximity Read ↗

Genotypic resistance in HIV-1-infected patients with persistently detectable low-level viremia while receiving highly active antiretroviral therapy.Semantic proximity Read ↗

Comparison of the dynamics of resistance-associated mutations to nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors after cessation of antiretroviral combination therapy.Semantic proximity Read ↗

Changes in human immunodeficiency virus type 1 populations after treatment interruption in patients failing antiretroviral therapy.Semantic proximity Read ↗

Lack of persistent drug-resistant mutations evaluated within and between treatment interruptions in chronically HIV-1-infected patients.Semantic proximity Read ↗

Rapid decline in detectability of HIV-1 drug resistance mutations after stopping therapySemantic proximity Read ↗

Rapid decline in detectability of HIV-1 drug resistance mutations after stopping therapy.Semantic proximity Read ↗

Evolution of human immunodeficiency virus type 1 populations after resumption of therapy following treatment interruption and shift in resistance genotype.Semantic proximity Read ↗

Evolution of human immunodeficiency virus type 1 (HIV-1) resistance mutations in nonnucleoside reverse transcriptase inhibitors (NNRTIs) in HIV-1-infected patients switched to antiretroviral therapy without NNRTIs.Semantic proximity Read ↗

Different viral rebound following discontinuation of antiretroviral therapy in cases of infection with viruses carrying L74V or thymidine-associated mutations.Semantic proximity Read ↗

Persistence of azidothymidine-resistant human immunodeficiency virus type 1 RNA genotypes in posttreatment sera.Semantic proximity Read ↗

Antiretroviral Treatment Interruptions Predict Female Genital Shedding of Genotypically Resistant HIV-1 RNASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.