Article
Genotypic resistance in HIV-1-infected patients with persistently detectable low-level viremia while receiving highly active antiretroviral therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Oct 2004
Nettles Richard E, Kieffer Tara L, Simmons Rachel P, Cofrancesco Joseph, Moore Richard D, Gallant Joel E, Persaud Deborah, Siliciano Robert F
Abstract excerpt
BACKGROUND: Technical limitations in the sensitivity of commercial genotyping methods may prevent clinicians from determining whether drug-resistant human immunodeficiency virus type 1 (HIV-1) is present in patients with low-level viremia. We performed ultrasensitive HIV-1 genotyping for patients with persistent plasma virus loads of 50-400 copies/mL to better define the prevalence of drug resistance and the most...
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