Article
Comparison of the dynamics of resistance-associated mutations to nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors after cessation of antiretroviral combination therapy.
Antimicrobial agents and chemotherapy - 1 Feb 2004
Wirden Marc, Delaugerre Constance, Marcelin Anne Genevieve, Ktorza Nadine, Ait Mohand Hocine, Dominguez Stephanie, Schneider Luminita, Ghosn Jade, Pauchard Michele, Costagliola Dominique, Katlama Christine, Calvez Vincent
Abstract excerpt
The dynamics of mutations associated with resistance to antiretroviral drugs were analyzed after cessation of therapy. The results showed that the kinetics of the shift to wild-type amino acid residues were significantly faster for protease inhibitors, intermediate for nonnucleoside reverse transcriptase inhibitors, and slower for nucleoside reverse transcriptase inhibitors.
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