Article
Influence of mannose-binding lectin genotypes and serostatus in allo-SCT: analysis of 131 recipients and donors.
Bone marrow transplantation - 1 Jan 2010
Neth O W, Bacher U, Das P, Zabelina T, Kabisch H, Kroeger N, Ayuk F, Lioznov M, Waschke O, Fehse B, Thiébaut R, Haston R M, Klein N, Zander A R
Abstract excerpt
Mannan-binding lectin (MBL) deficiency is determined by MBL gene polymorphisms and is associated with an increased infection risk. To clarify the role of MBL in Allo-SCT, 131 recipients-donors were analysed. MBL genotypes were determined by PCR and heteroduplex analyses, MBL serum levels by ELISA, and MBL oligomers by western blotting. MBL levels <400 ng/ml were associated with increased susceptibility to fungal...
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