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Article

Impact of Exon 1 polymorphism in the MBL2 gene on MBL serum levels and infection susceptibility in acute lymphoid leukemia.

Scientific reports - 2 Jan 2025

de Oliveira Leonardo Calheiros, de Souza Paulo Henrique Rodrigues, Barbosa Anderson Nogueira, Mineiro Luma Silva, Pontes Gemilson Soares

Abstract excerpt

Polymorphisms in the MBL2 gene exon 1 can decrease serum levels of mannose-binding lectin (MBL), increasing the risk of infection in immunocompromised individuals. This study evaluated the association between the polymorphism in exon 1 of the MBL2 gene, genotypes, serum MBL levels, and infection in 122 patients with acute lymphoid leukemia (ALL). The MBL*A allele exhibited the highest frequency (0.37) within the...

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Adolescent
Child
Exons
Gene Frequency
Mannose-Binding Lectin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Identifiers

PMID: 39747272
DOI: 10.1038/s41598-024-81971-1
PMCID: PMC11696297

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