Article
Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism.
Nature genetics - 1 Sept 2013
Pande Kalyan, Chen Changbin, Noble Suzanne M
Abstract excerpt
Among ∼5,000,000 fungal species, C. albicans is exceptional in its lifelong association with humans, either within the gastrointestinal microbiome or as an invasive pathogen. Opportunistic infections are generally ascribed to defective host immunity but may require specific microbial programs. Here we report that exposure of C. albicans to the mammalian gut triggers a developmental switch, driven by the Wor1...
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