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Suppression of Coronavirus Replication by Inhibition of the MEK Signaling Pathway

27 Dec 2006

Abstract excerpt

We previously demonstrated that infection of cultured cells with murine coronavirus mouse hepatitis virus (MHV) resulted in activation of the mitogen-activated protein kinase (Raf/MEK/ERK) signal transduction pathway (Y. Cai et al., Virology 355:152-163, 2006). Here we show that inhibition of the Raf/MEK/ERK signaling pathway by the MEK inhibitor UO126 significantly impaired MHV progeny production (a reduction of...

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PMID: 17079328
DOI: 10.1128/jvi.01705-06

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