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Article

Expression of a dominant allele of human ARF1 inhibits membrane traffic in vivo.

The Journal of cell biology - 1 Feb 1994

Zhang C J, Rosenwald A G, Willingham M C, Skuntz S, Clark J, Kahn R A

Abstract excerpt

ADP-ribosylation factor (ARF) proteins and inhibitory peptides derived from ARFs have demonstrated activities in a number of in vitro assays that measure ER-to-Golgi and intra-Golgi transport and endosome fusion. To better understand the roles of ARF proteins in vivo, stable cell lines were obtained from normal rat kidney (NRK) cells transfected with either wild-type or a dominant activating allele ([Q71L]) of...

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Source

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Identifiers

PMID: 8294513
DOI: 10.1083/jcb.124.3.289
PMCID: PMC2119943

Genes

ARF1
NRK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Expression of a dominant allele of human ARF1 inhibits membrane traffic in vivo.PMID 8294513Read ↗

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The amino terminus of ADP-ribosylation factor (ARF) is a critical determinant of ARF activities and is a potent and specific inhibitor of protein transport.Semantic proximity Read ↗

ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) Have Both Specific and Shared EffectorsSemantic proximity Read ↗

Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments.Semantic proximity Read ↗

Shared and specific functions of Arfs 1–5 at the Golgi revealed by systematic knockoutsSemantic proximity Read ↗

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