Article
Different subcellular localizations for the related interferon-induced GTPases, MuGBP-1 and MuGBP-2: implications for different functions?
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Nov 2000
Vestal D J, Gorbacheva V Y, Sen G C
Abstract excerpt
The guanylate-binding proteins (GBPs) are a family of 65-67-kDa proteins induced by both type I and type II interferons (IFN). Members of the GBP family of GTPases are among the most abundant IFN-gamma-induced proteins. GBPs contain an unusual GTP binding site, which is consistent with GBP hydrolysis of GTP to both GDP and GMP. In addition, six of the eight known GBPs have a carboxy-terminal CaaX motif for the...
Topics
- 3T3 Cells
- Animals
- Cells, Cultured
- Cytoplasmic Vesicles
- DNA-Binding Proteins
- GTP Phosphohydrolases
- GTP-Binding Proteins
- Interferon-gamma
- Intracellular Membranes
- Macrophages
- Mice
- Mutation
- Protein Prenylation
- Transfection