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Article

A critical role of a cellular membrane traffic protein in poliovirus RNA replication.

PLoS pathogens - 1 Nov 2008

Belov George A, Feng Qian, Nikovics Krisztina, Jackson Catherine L, Ehrenfeld Ellie

Abstract excerpt

Replication of many RNA viruses is accompanied by extensive remodeling of intracellular membranes. In poliovirus-infected cells, ER and Golgi stacks disappear, while new clusters of vesicle-like structures form sites for viral RNA synthesis. Virus replication is inhibited by brefeldin A (BFA), implicating some components(s) of the cellular secretory pathway in virus growth. Formation of characteristic vesicles...

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Identifiers

PMID: 19023417
DOI: 10.1371/journal.ppat.1000216
PMCID: PMC2581890

Genes

GBF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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