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Article

Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Apr 2003

Weeber Edwin J, Jiang Yong-Hui, Elgersma Ype, Varga Andrew W, Carrasquillo Yarimar, Brown Sarah E, Christian Jill M, Mirnikjoo Banefsheh, Silva Alcino, Beaudet Arthur L, Sweatt J David

Abstract excerpt

Angelman syndrome (AS) is a disorder of human cognition characterized by severe mental retardation and epilepsy. Recently, a mouse model for AS (Ube3a maternal null mutation) was developed that displays deficits in both context-dependent learning and hippocampal long-term potentiation (LTP). In the present studies, we examined the molecular basis for these LTP and learning deficits. Mutant animals exhibited a...

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Identifiers

PMID: 12684449
PMCID: PMC6742065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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