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Article

MCL-1 regulates the balance between autophagy and apoptosis

11 Apr 2011

Abstract excerpt

BCL-2 homologues lie at the interface between apoptosis and autophagy, regulating these two critical cellular pathways. However, the mechanisms controlling their coordinate regulation and the consequences on cellular survival are not fully understood. We recently showed that MCL-1 is a critical regulator of autophagy in cell lines and neurons. Our findings indicate that activation of apoptosis and autophagy is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21412051
DOI: 10.4161/auto.7.5.15098

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