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Article

Staphylococcus aureus virulence is enhanced by secreted factors that block innate immune defenses.

Journal of innate immunity - 1 Jan 2012

Jongerius Ilse, von Köckritz-Blickwede Maren, Horsburgh Malcolm J, Ruyken Maartje, Nizet Victor, Rooijakkers Suzan H M

Abstract excerpt

Staphylococcus aureus is a leading human pathogen that causes a large variety of diseases. In vitro studies have shown that S. aureus secretes several small proteins that block specific elements of the host innate immune system, but their role in bacterial pathogenicity is unknown. For instance, the extracellular complement-binding protein (Ecb) impairs complement activation by binding to the C3d domain of C3....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunity, Innate

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Source

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Identifiers

PMID: 22327617
DOI: 10.1159/000334604
PMCID: PMC3357151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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