Article
Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila.
Developmental biology - 1 Aug 2008
Jaklevic Burnley, Uyetake Lyle, Wichmann Anita, Bilak Amber, English Christopher N, Su Tin Tin
Abstract excerpt
In Drosophila, heterozygosity in the pro-apoptotic gene hid significantly reduces apoptosis that is induced by ionizing radiation (IR). Therefore, mechanisms that regulate Hid levels can potentially contribute to life-or-death decision of an irradiated cell. 3'UTR of hid mRNA contains 5 potential binding sites for bantam microRNA. Ectopic expression of ban attenuated apoptosis that results from ectopic expression...
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