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Article

HR repair pathway plays a crucial role in maintaining neural stem cell fate under irradiation stress.

Life science alliance - 1 Aug 2023

Xu Xiao, An Huanping, Wu Cheng, Sang Rong, Wu Litao, Lou Yuhan, Yang Xiaohang, Xi Yongmei

Abstract excerpt

Environmental stress can cause mutation or genomic instability in stem cells which, in some cases, leads to tumorigenesis. Mechanisms to monitor and eliminate these mutant stem cells remain elusive. Here, using the Drosophila larval brain as a model, we show that X-ray irradiation (IR) at the early larval stage leads to accumulation of nuclear Prospero (Pros), resulting in premature differentiation of neural stem...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37197982
DOI: 10.26508/lsa.202201802
PMCID: PMC10192720

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