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Mitochondrial DNA plays an equal role in influencing female and male longevity in centenarians.

Experimental gerontology - 1 Oct 2016

He Yong-Han, Lu Xiang, Tian Jiao-Yang, Yan Dong-Jing, Li Yu-Chun, Lin Rong, Perry Benjamin, Chen Xiao-Qiong, Yu Qin, Cai Wang-Wei, Kong Qing-Peng

Abstract excerpt

The mitochondrion is a double membrane-bound organelle which plays important functional roles in aging and many other complex phenotypes. Transmission of the mitochondrial genome in the matrilineal line causes the evolutionary selection sieve only in females. Theoretically, beneficial or neutral variations are more likely to accumulate and be retained in the female mitochondrial genome during evolution, which may...

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PMID: 27451341
DOI: 10.1016/j.exger.2016.07.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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