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Article

S-nitrosylation of connexin43 hemichannels elicits cardiac stress-induced arrhythmias in Duchenne muscular dystrophy mice.

JCI insight - 19 Dec 2019

Lillo Mauricio A, Himelman Eric, Shirokova Natalia, Xie Lai-Hua, Fraidenraich Diego, Contreras Jorge E

Abstract excerpt

Patients with Duchenne muscular dystrophy (DMD) commonly present with severe ventricular arrhythmias that contribute to heart failure. Arrhythmias and lethality are also consistently observed in adult Dmdmdx mice, a mouse model of DMD, after acute β-adrenergic stimulation. These pathological features were previously linked to aberrant expression and remodeling of the cardiac gap junction protein connexin43...

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Share to Adrenergic beta-Agonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connexin 43

Share to Dystrophin

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Source

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Identifiers

PMID: 31751316
DOI: 10.1172/jci.insight.130091
PMCID: PMC6975272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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