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Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes.

Cardiovascular research - 1 Jun 2017

Portero Vincent, Casini Simona, Hoekstra Maaike, Verkerk Arie O, Mengarelli Isabella, Belardinelli Luiz, Rajamani Sridharan, Wilde Arthur A M, Bezzina Connie R, Veldkamp Marieke W, Remme Carol Ann

Abstract excerpt

AIMS: Selective inhibition of cardiac late sodium current (INaL) is an emerging target in the treatment of ventricular arrhythmias. We investigated the electrophysiological effects of GS-458967 (GS967), a potent, selective inhibitor of INaL, in an overlap syndrome model of both gain and loss of sodium channel function, comprising cardiomyocytes derived from both human SCN5A-1795insD+/- induced pluripotent stem...

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PMID: 28430892
DOI: 10.1093/cvr/cvx077

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