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Article

Structural and kinetic effects of hypertrophic cardiomyopathy related mutations R146G/Q and R163W on the regulatory switching activity of rat cardiac troponin I.

Archives of biochemistry and biophysics - 1 Jul 2013

Zhou Zhiqun, Rieck Daniel, Li King-Lun, Ouyang Yexin, Dong Wen-Ji

Abstract excerpt

Mutations in cardiac troponin I (cTnI) that cause hypertrophic cardiomyopathy (HCM) have been reported to change the contractility of cardiac myofilaments, but the underlying molecular mechanism remains elusive. In this study, Förster resonance energy transfer (FRET) was used to investigate the specific structural and kinetic effects that HCM related rat cTnI mutations R146G/Q and R163W exert on Ca(2+) and myosin...

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Identifiers

PMID: 23246786
DOI: 10.1016/j.abb.2012.12.007
PMCID: PMC3616153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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